Anti-Malignant T cell amplified sequence 1抗体(ab89839)

概述

  • 产品名称Anti-Malignant T cell amplified sequence 1抗体
    参阅全部 Malignant T cell amplified sequence 1 一抗
  • 描述
    兔多克隆抗体to Malignant T cell amplified sequence 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (FKKFDEKENV SNCIQLKTSV IKGIKNQLIE QFPGIEPWLN QIMPKKDPVK) of Human Malignant T cell amplified sequence 1 (NP_054779).

  • 阳性对照
    • COLO205 cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab89839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
  • 组织特异性Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
  • 序列相似性Belongs to the MCTS1 family.
    Contains 1 PUA domain.
  • 结构域The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins.
  • 翻译后修饰Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • 细胞定位Cytoplasm. Nuclear relocalization after DNA damage.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ39637 antibody
    • Malignant T cell-amplified sequence 1 antibody
    • MCT 1 antibody
    • MCT-1 antibody
    • MCT1 antibody
    • MCTS 1 antibody
    • MCTS1 antibody
    • MCTS1_HUMAN antibody
    • Multiple copies T cell malignancies 1 antibody
    • Multiple copies T cell malignancies antibody
    • Multiple copies T-cell malignancies antibody
    • Oncogene MCT 1 antibody
    • Oncogene MCT1 antibody
    see all

Anti-Malignant T cell amplified sequence 1 antibody 图像

  • Anti-Malignant T cell amplified sequence 1 antibody (ab89839) at 1 µg/ml (in 5% skim milk / PBS buffer) + COLO205 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 21 kDa

Anti-Malignant T cell amplified sequence 1 antibody (ab89839)参考文献

ab89839 has not yet been referenced specifically in any publications.

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