Anti-MCTS1/MCT-1抗体(ab102678)
Key features and details
- Rabbit polyclonal to MCTS1/MCT-1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MCTS1/MCT-1抗体
参阅全部 MCTS1/MCT-1 一抗 -
描述
兔多克隆抗体to MCTS1/MCT-1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Recombinant fragment corresponding to Human MCTS1/MCT-1 aa 1-200.
Database link: AAH01013 -
阳性对照
- Jurkat whole cell lysate, 293T and A431 cell lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab102678于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 21 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 21 kDa. |
靶标
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功能
Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. -
组织特异性
Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. -
序列相似性
Belongs to the MCTS1 family.
Contains 1 PUA domain. -
结构域
The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins. -
翻译后修饰
Phosphorylation is critical for stabilization and promotion of cell proliferation. -
细胞定位
Cytoplasm. Nuclear relocalization after DNA damage. - Information by UniProt
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数据库链接
- Entrez Gene: 28985 Human
- Entrez Gene: 68995 Mouse
- Omim: 300587 Human
- SwissProt: Q9ULC4 Human
- SwissProt: Q9DB27 Mouse
- Unigene: 102696 Human
- Unigene: 670803 Human
- Unigene: 262453 Mouse
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别名
- FLJ39637 antibody
- Malignant T cell amplified sequence 1 antibody
- Malignant T cell-amplified sequence 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab102678 尚未被引用在任何文献中。