概述

  • 产品名称
  • 描述
    兔多克隆抗体to MAL2
  • 经测试应用
    适用于: ELISA, ICC, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the N-terminal domain of human MAL2

性能

应用

Our Abpromise guarantee covers the use of ab75347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
ICC 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 19 kDa.

靶标

  • 功能
    Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
  • 组织特异性
    Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
  • 序列相似性
    Belongs to the MAL family.
    Contains 1 MARVEL domain.
  • 细胞定位
    Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MAL 2 antibody
    • MAL proteolipid protein 2 antibody
    • Mal, T cell differentiation protein 2 antibody
    • mal2 antibody
    • MAL2_HUMAN antibody
    • Protein MAL2 antibody
    see all

文献

This product has been referenced in:
  • Li J  et al. The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PLoS One 12:e0178515 (2017). IHC-P ; Human . Read more (PubMed: 28562687) »
  • Katz E  et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 6:e17083 (2011). WB . Read more (PubMed: 21347235) »

See all 2 Publications for this product

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