概述

  • 产品名称Anti-MAK抗体
    参阅全部 MAK 一抗
  • 描述
    小鼠单克隆抗体to MAK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: PPKQQSQEKP PQTLFPSIVK NMPTKPNGTL SHKSGRRRWG QTIFKSGDSW EELEDYDFGA SHSKKPSMGV FKEKRKKDSP FRQQVKMAVI SLSAHQFPTL , corresponding to amino acids 358-457 of Human MAK

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab55453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
    • 组织特异性Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
    • 疾病相关Defects in MAK are the cause of retinitis pigmentosa type 62 (RP62) [MIM:614181]. RP62 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
      Contains 1 protein kinase domain.
    • 翻译后修饰Autophosphorylated. Phosphorylated on serine and threonine residues.
    • 细胞定位Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Midbody. Cell projection > cilium > photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • intestinal cell kinase antibody
      • dJ417M14.2 antibody
      • fj04c02 antibody
      • Ick antibody
      • Mak antibody
      • MAK_HUMAN antibody
      • Male germ cell associated kinase antibody
      • Male germ cell-associated kinase antibody
      • male germ cell-associated kinase retinal-enriched isoform antibody
      • OTTHUMP00000016025 antibody
      • Rck antibody
      • RP62 antibody
      • Serine/threonine protein kinase MAK antibody
      • Serine/threonine-protein kinase MAK antibody
      • testicular secretory protein Li 28 antibody
      • wu:fj04c02 antibody
      • zgc:56603 antibody
      see all

    Anti-MAK antibody 图像



    • Predicted band size : 71 kDa
      MAK antibody (ab55453) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-MAK antibody (ab55453)参考文献

    ab55453 has not yet been referenced specifically in any publications.

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