概述

  • 产品名称Anti-MAGOH抗体
    参阅全部 MAGOH 一抗
  • 描述
    小鼠单克隆抗体to MAGOH
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-111 of Human MAGOH

性能

应用

Our Abpromise guarantee covers the use of ab55440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.
    • 组织特异性Ubiquitous.
    • 序列相似性Belongs to the mago nashi family.
    • 细胞定位Nucleus. Nucleus speckle. Cytoplasm. Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Mago nashi homolog proliferation associated (Drosophila) antibody
      • Mago nashi protein homolog antibody
      • magoh antibody
      • MAGOHA antibody
      • MGN_HUMAN antibody
      • Protein mago nashi homolog antibody
      see all

    Anti-MAGOH antibody 图像



    • Predicted band size : 17 kDa
      MAGOH antibody (ab55440) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-MAGOH antibody (ab55440)参考文献

    ab55440 has not yet been referenced specifically in any publications.

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