概述

  • 产品名称
  • 描述
    兔多克隆抗体to MAGED1
  • 特异性
    This antibody is specific for MAGED1.
  • 经测试应用
    适用于: IHC-P, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide (10-30 aa in length) in the region of 466~481 of human MAGED1.

  • 阳性对照
    • A549 lysate and breast carcinoma tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab38492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 86 kDa (predicted molecular weight: 86 kDa).
ELISA 1/1000.

靶标

  • 功能
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • 组织特异性
    Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
  • 序列相似性
    Contains 1 MAGE domain.
  • 细胞定位
    Cytoplasm. Cell membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DLXIN 1 antibody
    • MAGD1_HUMAN antibody
    • MAGE D1 antigen antibody
    • MAGE tumor antigen CCF antibody
    • MAGE-D1 antigen antibody
    • Maged1 antibody
    • Melanoma antigen family D 1 antibody
    • Melanoma associated antigen D1 antibody
    • Melanoma-associated antigen D1 antibody
    • Neurotrophin receptor interacting MAGE homolog antibody
    • Neurotrophin receptor-interacting MAGE homolog antibody
    • NRAGE antibody
    • PP2250 antibody
    see all

Anti-MAGED1 antibody 图像

  • Anti-MAGED1 antibody (ab38492) at 1/100 dilution + A549 lysate

    Predicted band size : 86 kDa
    Observed band size : 86 kDa
    Additional bands at : 30 kDa,45 kDa,50 kDa,55 kDa,60 kDa,65 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with ab38492, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry.

Anti-MAGED1 antibody (ab38492)参考文献

ab38492 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab38492.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册