Anti-MAGE 1抗体[SPM282] (ab25834)

概述

  • 产品名称
    Anti-MAGE 1抗体[SPM282]
    参阅全部 MAGE 1 一抗
  • 描述
    小鼠单克隆抗体[SPM282] to MAGE 1
  • 特异性
    ab25834 recognises MAGE-1.
  • 经测试应用
    适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Dog
  • 免疫原

    Partially purified, full length recombinant human MAGE-1 protein

  • 阳性对照
    • Colo32 cells Germ cells in testis.

性能

应用

Our Abpromise guarantee covers the use of ab25834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
IHC-P 1/25. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 44 kDa.

靶标

  • 功能
    May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • 组织特异性
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
  • 序列相似性
    Contains 1 MAGE domain.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Antigen MZ2 E antibody
    • Antigen MZ2-E antibody
    • Cancer/testis antigen 1.1 antibody
    • cancer/testis antigen family 1, member 1 antibody
    • CT1.1 antibody
    • MAGA1_HUMAN antibody
    • MAGE 1 antigen antibody
    • MAGE-1 antigen antibody
    • MAGE1 antibody
    • MAGE1A antibody
    • MAGEA1 antibody
    • Melanoma antigen 1 antibody
    • Melanoma antigen family A 1 (directs expression of antigen MZ2 E) antibody
    • Melanoma antigen family A 1 antibody
    • Melanoma antigen MAGE 1 antibody
    • Melanoma associated antigen 1 antibody
    • Melanoma associated antigen MZ2 E antibody
    • Melanoma-associated antigen 1 antibody
    • MGC9326 antibody
    see all

图片

  • ab25834 staining MAGE 1 in Human testis by Immunohistochemisty of formalin-fixed, parrafin embedded tissue.

文献

ab25834 has not yet been referenced specifically in any publications.

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