概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 序列MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIV

技术指标

Our Abpromise guarantee covers the use of ab113702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: 100% dH2O

常规信息

  • 别名
    • AA545192
    • Basic leucine zipper transcription factor MafG
    • C630022N07Rik
    • hMAF
    • MAFG
    • MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
    • MAFG_HUMAN
    • MGC13090
    • MGC20149
    • RP23 84C12.9
    • Transcription factor MafG
    • V maf musculoaponeurotic fibrosarcoma oncogene homolog G
    • V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
    see all
  • 功能Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
  • 组织特异性Highly expressed in skeletal muscle. Also expressed in heart and brain.
  • 序列相似性Belongs to the bZIP family. Maf subfamily.
    Contains 1 bZIP domain.
  • 翻译后修饰Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
    Sumoylation at Lys-14 is required for active transcriptional repression.
  • 细胞定位Nucleus.
  • Information by UniProt

MAFG peptide (ab113702)参考文献

ab113702 has not yet been referenced specifically in any publications.

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