概述

  • 产品名称Anti-MAFG抗体
    参阅全部 MAFG 一抗
  • 描述
    兔多克隆抗体to MAFG
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 72-121 (RVTQKEELEK QKAELQQEVE KLASENASMK LELDALRSKY EALQTFARTV) of human MAFG (NP_002350).

  • 阳性对照
    • Jurkat cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab86524 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
  • 组织特异性Highly expressed in skeletal muscle. Also expressed in heart and brain.
  • 序列相似性Belongs to the bZIP family. Maf subfamily.
    Contains 1 bZIP domain.
  • 翻译后修饰Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
    Sumoylation at Lys-14 is required for active transcriptional repression.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA545192 antibody
    • Basic leucine zipper transcription factor MafG antibody
    • C630022N07Rik antibody
    • hMAF antibody
    • MAFG antibody
    • MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) antibody
    • MAFG_HUMAN antibody
    • MGC13090 antibody
    • MGC20149 antibody
    • RP23 84C12.9 antibody
    • Transcription factor MafG antibody
    • V maf musculoaponeurotic fibrosarcoma oncogene homolog G antibody
    • V-maf musculoaponeurotic fibrosarcoma oncogene homolog G antibody
    see all

Anti-MAFG antibody 图像



  • Predicted band size : 18 kDa
    Western blot analysis of 293T cell lysate labeling MAFG with ab86524 at 1.0µg/ml.
  • Anti-MAFG antibody (ab86524) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 18 kDa
    Observed band size : 18 kDa

Anti-MAFG antibody (ab86524)参考文献

ab86524 has not yet been referenced specifically in any publications.

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