概述

  • 产品名称Anti-MAFA抗体
    参阅全部 MafA 一抗
  • 描述
    小鼠单克隆抗体to MAFA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: LEERFSDDQL VSMSVRELNR QLRGFSKEEV IRLKQKRRTL KNRGYAQSCR FKRVQQRHIL ESEKCQLQSQ VEQLKLEVGR LAKERDL, corresponding to amino acids 222-309 of Human MAFA

性能

应用

Our Abpromise guarantee covers the use of ab57807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
    • 序列相似性Belongs to the bZIP family. Maf subfamily.
      Contains 1 bZIP domain.
    • 翻译后修饰Ubiquitinated, leading to its degradation by the proteasome.
      Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway.
    • 细胞定位Nucleus. Detected in nuclei of pancreas islet beta cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HMafA antibody
      • Mafa antibody
      • MAFA_HUMAN antibody
      • Pancreatic beta cell specific transcriptional activator antibody
      • Pancreatic beta-cell-specific transcriptional activator antibody
      • RIPE3b1 antibody
      • Transcription factor MafA antibody
      • Transcription factor RIPE3b1 antibody
      • v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) antibody
      • v maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody
      • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody
      see all

    Anti-MAFA antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57807 MAFA antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    Anti-MAFA antibody (ab57807)参考文献

    ab57807 has not yet been referenced specifically in any publications.

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