概述

  • 产品名称
  • 描述
    兔多克隆抗体to MAEA
  • 特异性
    ab65239 detects endogenous levels of total MAEA protein.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from an internal sequence of human MAEA.

  • 阳性对照
    • COLO205 cell extracts.

性能

应用

Our Abpromise guarantee covers the use of ab65239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20000.
WB 1/500 - 1/1000. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).

靶标

  • 功能
    Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Contains 1 CTLH domain.
    Contains 1 LisH domain.
  • 发展阶段
    Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis.
  • 细胞定位
    Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Localized as nuclear speckled-like pattern.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110030D19Rik antibody
    • Cell proliferation inducing gene 5 protein antibody
    • Cell proliferation-inducing gene 5 protein antibody
    • EMLP antibody
    • EMP antibody
    • Erythroblast macrophage protein antibody
    • GID complex subunit 9 FYV10 homolog antibody
    • GID9 antibody
    • HLC 10 antibody
    • HLC-10 antibody
    • HLC10 antibody
    • Human lung cancer oncogene 10 protein antibody
    • Lung cancer related protein 10 antibody
    • Macrophage erythroblast attacher antibody
    • MAEA antibody
    • MAEA_HUMAN antibody
    • MGC93683 antibody
    • PIG5 antibody
    • Proliferation inducing gene 5 antibody
    see all

图片

  • All lanes : Anti-MAEA antibody (ab65239) at 1/500 dilution

    Lane 1 : COLO205 cell extract
    Lane 2 : COLO205 cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 45 kDa
    Observed band size : 45 kDa

实验方案

文献

This product has been referenced in:
  • Mao X  et al. Evaluation of erythroblast macrophage protein related to erythroblastic islands in patients with hematopoietic stem cell transplantation. Eur J Med Res 18:9 (2013). WB ; Human . Read more (PubMed: 23566571) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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