Anti-MAdCAM1抗体[MECA-367] (Biotin) (ab25021)

概述

  • 产品名称
    Anti-MAdCAM1抗体[MECA-367] (Biotin)
    参阅全部 MAdCAM1 一抗
  • 描述
    大鼠单克隆抗体[MECA-367] to MAdCAM1 (Biotin)
  • 偶联物
    Biotin
  • 经测试应用
    适用于: Other, Flow Cyt, IHC-Fr, Blocking, IP, WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.

  • 表位
    ab25021 reacts with an epitope located in the first domain of MAdCAM1.
  • 常规说明


    ab25021 blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer’s patch HEV In vivo.

性能

应用

Our Abpromise guarantee covers the use of ab25021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Other Use at an assay dependent concentration.
AP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use a concentration of 1 µg/ml.
Blocking Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.

靶标

  • 功能
    Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
  • 组织特异性
    Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
  • 序列相似性
    Contains 2 Ig-like (immunoglobulin-like) domains.
  • 翻译后修饰
    The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Addressin mucosal antibody
    • hMAdCAM 1 antibody
    • hMAdCAM-1 antibody
    • MACAM1 antibody
    • MADCA_HUMAN antibody
    • MAdCAM 1 antibody
    • MAdCAM-1 antibody
    • Madcam1 antibody
    • Mucosal addressin cell adhesion molecule 1 antibody
    • Mucosal vascular addressin cell adhesion molecule 1 antibody
    see all

文献

ab25021 has not yet been referenced specifically in any publications.

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