Anti-Macrophage Inflammatory Protein 4抗体(ab9849)


  • 产品名称
    Anti-Macrophage Inflammatory Protein 4抗体
    参阅全部 Macrophage Inflammatory Protein 4 一抗
  • 描述
    兔多克隆抗体to Macrophage Inflammatory Protein 4
  • 经测试应用
    适用于: WB, ELISA, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Highly pure (>98%) recombinant hMIP-4 (human macrophage inflammatory protein-4)



Our Abpromise guarantee covers the use of ab9849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明
    Neutralization:To yield one-half maximal inhibition [ND50] of the biological activity of hMIP-4 (100 ng/ml), a concentration of 8.0 - 10.0 µg/ml of this antibody is required.

    ELISA:To detect hMIP-4 by direct ELISA (using 100µl/well antibody solution) a concentration of at least 0.5µg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant hMIP-4.

    Western Blot:To detect hMIP-4 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMIP-4 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
  • 靶标

    • 功能
      Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
    • 组织特异性
      Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.
    • 序列相似性
      Belongs to the intercrine beta (chemokine CC) family.
    • 细胞定位
    • Information by UniProt
    • 数据库链接
    • 别名
      • Alternative macrophage activation associated CC chemokine 1 antibody
      • Alternative macrophage activation-associated CC chemokine 1 antibody
      • AMAC-1 antibody
      • AMAC1 antibody
      • CC chemokine PARC antibody
      • CCL18 antibody
      • CCL18(4-69) antibody
      • CCL18_HUMAN antibody
      • CKb7 antibody
      • DC-CK1 antibody
      • DCCK1 antibody
      • DCCK1 antibody
      • Dendritic cell chemokine 1 antibody
      • Macrophage inflammatory protein 4 antibody
      • MIP-4 antibody
      • MIP4 antibody
      • PARC antibody
      • Pulmonary and activation regulated chemokine antibody
      • Pulmonary and activation-regulated chemokine antibody
      • SCYA18 antibody
      • Small inducible cytokine A18 antibody
      • Small inducible cytokine A18 antibody
      • Small-inducible cytokine A18 antibody
      see all


    Anti-Macrophage Inflammatory Protein 4 antibody (ab9849)参考文献

    This product has been referenced in:
    • Su S  et al. Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer. Cell Res 27:461-482 (2017). Blocking ; Human . Read more (PubMed: 28290464) »
    • Su S  et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 25:605-20 (2014). Read more (PubMed: 24823638) »

    See all 2 Publications for this product

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    The isotype of ab9849 is rabbit IgG so you could choose a rabbit IgG antibody as isotype control in neutralising experiments.

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