概述

  • 产品名称Anti-Macrophage抗体[5/9]
    参阅全部 Macrophage 一抗
  • 描述
    小鼠单克隆抗体[5/9] to Macrophage
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A cell suspension containing osteoclasts from osteoclastomas (Human).

  • 常规说明


    This antibody may be used as a macrophage cell marker, and may be useful for the identification of osteoclasts in tissues to study developmental pathobiology.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度IgG fraction
  • Primary antibody说明This antibody may be used as a macrophage cell marker, and may be useful for the identification of osteoclasts in tissues to study developmental pathobiology.
  • 克隆单克隆
  • 克隆编号5/9
  • 骨髓瘤P3x63-Ag8.653
  • 同种型IgG1
  • 轻链类型unknown
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab20214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.

靶标

  • 相关性Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and promonocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becomming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Among cells that are now recognised as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).
  • 别名
    • macrophages antibody

Anti-Macrophage antibody [5/9] (ab20214)参考文献

This product has been referenced in:
  • Horton MA  et al. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res 45:5663-9 (1985). Read more (PubMed: 4053038) »

See 1 Publication for this product

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