Anti-M6PR (cation independent)抗体[MEM-238] (FITC) (ab33389)

概述

  • 产品名称Anti-M6PR (cation independent)抗体[MEM-238] (FITC)
    参阅全部 M6PR (cation independent) 一抗
  • 描述
    小鼠单克隆抗体[MEM-238] to M6PR (cation independent) (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human, Monkey, Rhesus monkey
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 表位Located in the region between extracellular domains 2 and 5 (aa 192-697) of IGFII Receptor.

性能

应用

Our Abpromise guarantee covers the use of ab33389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明FACS: Use 10ul neat antibody to label 106 cells in 100ul.
    Membrane permeabilisation is required for this application.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
    • 序列相似性Belongs to the MRL1/IGF2R family.
      Contains 1 fibronectin type-II domain.
    • 结构域Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
    • 细胞定位Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 300 kDa mannose 6 phosphate receptor antibody
      • 300 kDa mannose 6-phosphate receptor antibody
      • Cation independent mannose 6 phosphate receptor antibody
      • Cation-independent mannose-6-phosphate receptor antibody
      • CD222 antibody
      • CD222 antigen antibody
      • CI Man 6 P receptor antibody
      • CI Man-6-P receptor antibody
      • CI MPR antibody
      • CI-M6PR antibody
      • CI-MPR antibody
      • CIMPR antibody
      • IGF 2 receptor antibody
      • IGF 2R antibody
      • IGF II receptor antibody
      • IGF-II receptor antibody
      • IGF2 receptor antibody
      • Igf2r antibody
      • Insulin like growth factor 2 receptor antibody
      • Insulin like growth factor II receptor antibody
      • Insulin-like growth factor 2 receptor antibody
      • Insulin-like growth factor II receptor antibody
      • M6P R antibody
      • M6P/IGF2 receptor antibody
      • M6P/IGF2R antibody
      • M6PR antibody
      • mannose 6 phosphate receptor antibody
      • mannose 6 phosphate receptor, cation independent antibody
      • MPR 300 antibody
      • MPR300 antibody
      • MPRI antibody
      • MPRI_HUMAN antibody
      see all

    Anti-M6PR (cation independent) antibody [MEM-238] (FITC) 图像

    • ab33389 staining human peripheral blood monocytes, following membrane permeablisation.

    Anti-M6PR (cation independent) antibody [MEM-238] (FITC) (ab33389)参考文献

    This product has been referenced in:
    • Leksa V  et al. TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen. J Cell Sci 118:4577-86 (2005). Read more (PubMed: 16179614) »

    See 1 Publication for this product

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