Anti-M6PR (cation independent)抗体(ab61774)

概述

  • 产品名称Anti-M6PR (cation independent)抗体
    参阅全部 M6PR (cation independent) 一抗
  • 描述
    兔多克隆抗体to M6PR (cation independent)
  • 特异性ab61774 detects endogenous levels of total Mannose 6 Phosphate Receptor (Cation independent) protein.
  • 经测试应用适用于: IHC-P, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic non-phosphopeptide derived from human Mannose 6 Phosphate Receptor (Cation independent) around the phosphorylation site of serine 2484 (D-D-S-D-E).

  • 阳性对照
    • Human lung carcinoma tissue, 293 cell extracts and HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab61774 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100.
ELISA 1/20000.
ICC/IF 1/500 - 1/1000.

靶标

  • 功能Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
  • 序列相似性Belongs to the MRL1/IGF2R family.
    Contains 1 fibronectin type-II domain.
  • 结构域Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
  • 细胞定位Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 300 kDa mannose 6 phosphate receptor antibody
    • 300 kDa mannose 6-phosphate receptor antibody
    • Cation independent mannose 6 phosphate receptor antibody
    • Cation-independent mannose-6-phosphate receptor antibody
    • CD222 antibody
    • CD222 antigen antibody
    • CI Man 6 P receptor antibody
    • CI Man-6-P receptor antibody
    • CI MPR antibody
    • CI-M6PR antibody
    • CI-MPR antibody
    • CIMPR antibody
    • IGF 2 receptor antibody
    • IGF 2R antibody
    • IGF II receptor antibody
    • IGF-II receptor antibody
    • IGF2 receptor antibody
    • Igf2r antibody
    • Insulin like growth factor 2 receptor antibody
    • Insulin like growth factor II receptor antibody
    • Insulin-like growth factor 2 receptor antibody
    • Insulin-like growth factor II receptor antibody
    • M6P R antibody
    • M6P/IGF2 receptor antibody
    • M6P/IGF2R antibody
    • M6PR antibody
    • mannose 6 phosphate receptor antibody
    • mannose 6 phosphate receptor, cation independent antibody
    • MPR 300 antibody
    • MPR300 antibody
    • MPRI antibody
    • MPRI_HUMAN antibody
    see all

Anti-M6PR (cation independent) antibody 图像

  • ab61774 at 1/50 - 1/100 dilution staining Mannose 6 Phosphate (Cation independent) in human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
  • ab61774 at 1/500 - 1/1000 dilution staining Mannose 6 Phosphate Receptor (Cation independent) in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-M6PR (cation independent) antibody (ab61774)参考文献

ab61774 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab61774.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"