概述
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产品名称Anti-LYST抗体
参阅全部 LYST 一抗 -
描述小鼠单克隆抗体to LYST
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宿主Mouse
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经测试应用适用于: ELISA, Sandwich ELISAmore details
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种属反应性与反应: Recombinant fragment
预测可用于: Human
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免疫原
Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).
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常规说明
Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab220481 as a replacement.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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存储溶液pH: 7.20
Constituent: 99% PBS -
Concentration information loading... -
纯度Protein A purified
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克隆单克隆
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同种型IgG2b
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轻链类型kappa
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab118121 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA | Use at an assay dependent dilution. | |
| Sandwich ELISA | Use a concentration of 10 µg/ml. |
靶标
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功能May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
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组织特异性Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
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疾病相关Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
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序列相似性Contains 1 BEACH domain.
Contains 7 WD repeats. -
细胞定位Cytoplasm.
- Information by UniProt
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数据库链接
- Entrez Gene: 1130 Human
- Omim: 606897 Human
- SwissProt: Q99698 Human
- Unigene: 532411 Human
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别名
- Beige homolog antibody
- beige protein antibody
- Chediak-Higashi syndrome 1 antibody
see all
图片
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![Sandwich ELISA - Anti-LYST antibody [3H1] (ab118121)](http://www.abcam.cn/ps/datasheet/images/118/ab118121/LYST-Primary-antibodies-ab118121-1.jpg)
Sandwich ELISA - Anti-LYST antibody [3H1] (ab118121)Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.
文献
ab118121 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"