Anti-LYST抗体(ab118121)

概述

• 产品名称Anti-LYST抗体
  参阅全部 LYST 一抗
• 描述
  小鼠单克隆抗体to LYST
• 经测试应用适用于: ELISA, Sandwich ELISAmore details
• 种属反应性
  与反应: Recombinant fragment
  预测可用于: Human
• 免疫原

  Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液pH: 7.20
  Constituent: 99% PBS
• Concentration information loading...
• 纯度Protein A purified
• 克隆单克隆
• 同种型IgG2b
• 轻链类型kappa
• 研究领域
  • Signal Transduction
  • Protein Trafficking
  • Organelle Proteins

  • Signal Transduction
  • Protein Trafficking
  • Vesicle Transport
  • Regulation

相关产品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

应用

靶标

• 功能May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
• 组织特异性Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
• 疾病相关Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
• 序列相似性Contains 1 BEACH domain.
  Contains 7 WD repeats.
• 细胞定位Cytoplasm.

• Target information above from: UniProt accession Q99698 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 1130 Human
  • Omim: 606897 Human
  • SwissProt: Q99698 Human
  • Unigene: 532411 Human
• 别名
  • Beige homolog antibody
  • beige protein antibody
  • Chediak-Higashi syndrome 1 antibody

  • CHS antibody
  • CHS1 antibody
  • Lysosomal-trafficking regulator antibody
  • LYST antibody
  • LYST_HUMAN antibody
  • OTTHUMP00000038327 antibody

  see all