概述

  • 产品名称Anti-LYST抗体
  • 描述
    小鼠单克隆抗体to LYST
  • 经测试应用适用于: ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-101 of Human LYST with proprietary tag (NP_000072).

性能

应用

Our Abpromise guarantee covers the use of ab118121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

靶标

  • 功能May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
  • 组织特异性Abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain.
  • 疾病相关Defects in LYST are the cause of Chediak-Higashi syndrome (CHS) [MIM:214500]. CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT).
  • 序列相似性Contains 1 BEACH domain.
    Contains 7 WD repeats.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beige homolog antibody
    • beige protein antibody
    • Chediak-Higashi syndrome 1 antibody
    • CHS antibody
    • CHS1 antibody
    • Lysosomal-trafficking regulator antibody
    • LYST antibody
    • LYST_HUMAN antibody
    • OTTHUMP00000038327 antibody
    see all

Anti-LYST antibody 图像

  • Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.

Anti-LYST antibody (ab118121)参考文献

ab118121 has not yet been referenced specifically in any publications.

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