Anti-Lysosomal acid lipase抗体(ab89771)

概述

  • 产品名称Anti-Lysosomal acid lipase抗体
    参阅全部 Lysosomal acid lipase 一抗
  • 描述
    小鼠多克隆抗体to Lysosomal acid lipase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human Lysosomal acid lipase, amino acids 1-399 (AAH12287.1)

  • 阳性对照
    • Human pancreas tissue lysate, Lysosomal acid lipase transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.

靶标

  • 功能Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
  • 疾病相关Defects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
    Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset.
  • 序列相似性Belongs to the AB hydrolase superfamily. Lipase family.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acid cholesteryl ester hydrolase antibody
    • CESD antibody
    • cholesterol ester hydrolase antibody
    • cholesterol ester storage disease antibody
    • Cholesteryl esterase antibody
    • Hydrolase deficiency antibody
    • LAL antibody
    • LAL deficiency cholesterol ester antibody
    • LICH_HUMAN antibody
    • lipA antibody
    • LIPA deficiency antibody
    • Lipase A antibody
    • lipase A, lysosomal acid, cholesterol esterase antibody
    • lysosomal acid lipase antibody
    • lysosomal acid lipase deficiency antibody
    • Lysosomal acid lipase/cholesteryl ester hydrolase antibody
    • Sterol esterase antibody
    see all

Anti-Lysosomal acid lipase antibody 图像

  • Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg

    Predicted band size : 45 kDa
    Observed band size : 45 kDa
  • All lanes : Anti-Lysosomal acid lipase antibody (ab89771) at 1 µg/ml

    Lane 1 : Lysosomal acid lipase transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 45 kDa
    Observed band size : 45 kDa

Anti-Lysosomal acid lipase antibody (ab89771)参考文献

ab89771 has not yet been referenced specifically in any publications.

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