Anti-Lysosomal acid lipase/LAL抗体(ab89771)
Key features and details
- Mouse polyclonal to Lysosomal acid lipase/LAL
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Lysosomal acid lipase/LAL抗体
参阅全部 Lysosomal acid lipase/LAL 一抗 -
描述
小鼠多克隆抗体to Lysosomal acid lipase/LAL -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human Lysosomal acid lipase/LAL. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (AAH12287.1)
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阳性对照
- Human pancreas tissue lysate, Lysosomal acid lipase/LAL transfected 293T cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89771于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.
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说明 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. |
靶标
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功能
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. -
疾病相关
Defects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. -
序列相似性
Belongs to the AB hydrolase superfamily. Lipase family. -
细胞定位
Lysosome. - Information by UniProt
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数据库链接
- Entrez Gene: 3988 Human
- Omim: 278000 Human
- SwissProt: P38571 Human
- Unigene: 643030 Human
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别名
- Acid cholesteryl ester hydrolase antibody
- CESD antibody
- cholesterol ester hydrolase antibody
see all
图片
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Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg
Predicted band size: 45 kDa
Observed band size: 45 kDa -
All lanes : Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml
Lane 1 : Lysosomal acid lipase/LAL transfected 293T cell lysate
Lane 2 : Non-transfected lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
Observed band size: 45 kDa
数据表及文件
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Datasheet download
文献 (0)
ab89771 尚未被引用在任何文献中。