概述

  • 产品名称Anti-LY75抗体[RC38]
    参阅全部 LY75 一抗
  • 描述
    小鼠单克隆抗体[RC38] to LY75
  • 特异性RC38 stains over 95% of primary renal cell carcinomas and 60% of metastases of renal cell carcinoma and glomerular visceral epithelium and proximal tubules in normal kidney (cytoplasmic). It does not stain epithelial cells of non renal malignancies.
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A mouse was immunized with renal cell carcinoma homogenate. After fusing the spleen cells from this mouse with myeloma cells, antibody producing cells were screened on thin sections of various human tissues.

性能

应用

Our Abpromise guarantee covers the use of ab2489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr
  • 应用说明IHC-Fr: Use at an assay dependent concentration.
    Supernatant: for frozen tissue sections it can be diluted 1:20 in PBS/1%BSA.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
    • 组织特异性Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
    • 序列相似性Contains 10 C-type lectin domains.
      Contains 1 fibronectin type-II domain.
      Contains 1 ricin B-type lectin domain.
    • 翻译后修饰N-glycosylated.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C-type lectin domain family 13 member B antibody
      • CD 205 antibody
      • CD205 antibody
      • CD205 antigen antibody
      • CLEC 13B antibody
      • CLEC13B antibody
      • DEC 205 antibody
      • DEC-205 antibody
      • DEC205 antibody
      • gp200 antibody
      • gp200 MR6 antibody
      • gp200-MR6 antibody
      • LY 75 antibody
      • Ly-75 antibody
      • LY75 antibody
      • LY75_HUMAN antibody
      • Lymphocyte antigen 75 antibody
      • Renal Cell Carcinoma (gp200) antibody
      see all

    Anti-LY75 antibody [RC38] 图像

    • ab2489 staining human renal cell carcinoma by Immunohistochemistry (frozen sections).

    Anti-LY75 antibody [RC38] (ab2489)参考文献

    ab2489 has not yet been referenced specifically in any publications.

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