概述

  • 产品名称
    Anti-LXR beta抗体
    参阅全部 LXR beta 一抗
  • 描述
    兔多克隆抗体to LXR beta
  • 经测试应用
    适用于: IP, ChIP, ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Guinea pig, Dog
  • 免疫原

    A region within synthetic peptide: PWPGGPDPDV PGTDEASSAC STDWVIPDPE EEPERKRKKG PAPKMLGHEL, corresponding to N terminal amino acids 37-86 of Human LXR beta

  • 阳性对照
    • Transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab56237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution. PubMed: 20951680
ChIP Use at an assay dependent dilution. PubMed: 20599735
ICC/IF Use at an assay dependent dilution.
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 56 kDa (predicted molecular weight: 51 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Liver X nuclear receptor beta antibody
    • Liver X receptor beta antibody
    • LX receptor beta antibody
    • LXR b antibody
    • LXR beta antibody
    • LXRB antibody
    • NER antibody
    • NER I antibody
    • NER1 antibody
    • NR1H 2 antibody
    • NR1H2 antibody
    • NR1H2_HUMAN antibody
    • Nuclear orphan receptor LXR beta antibody
    • Nuclear receptor NER antibody
    • Nuclear receptor subfamily 1 group H member 2 antibody
    • OR-1 antibody
    • Oxysterols receptor LXR-beta antibody
    • RIP15 antibody
    • Steroid hormone nuclear receptor NER antibody
    • Ubiquitously-expressed nuclear receptor antibody
    • UNR antibody
    see all

图片

  • Anti-LXR beta antibody (ab56237) at 1.25 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 51 kDa
    Observed band size : 56 kDa (why is the actual band size different from the predicted?)

文献

This product has been referenced in:
  • McDonald G  et al. Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. J Clin Invest 124:712-24 (2014). Human . Read more (PubMed: 24463447) »
  • Wan X  et al. 5'-AMP-activated protein kinase-activating transcription factor 1 cascade modulates human monocyte-derived macrophages to atheroprotective functions in response to heme or metformin. Arterioscler Thromb Vasc Biol 33:2470-80 (2013). Read more (PubMed: 24051143) »

See all 8 Publications for this product

客户评价及客户问答

Thank you for your enquiry and your interest in our products.

We have several antibodies against LXR beta (ab24361, ab56237, ab58089, ab58092, ab76983, ab106473) . The tested application/species/unit size can be found on the on-line product d...

Read More
Application
Immunocytochemistry/ Immunofluorescence
Sample
Hamster Cell (CHO K1 cells expressing Human LXR beta)
Specification
CHO K1 cells expressing Human LXR beta
Fixative
Formaldehyde
Blocking step
TBS + 3% Dried Milk + 0.1 % Triton X-100 as blocking agent for 20 minute(s) · Concentration: 3% · Temperature: 22°C
Username

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Verified customer

提交于 Jul 30 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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