Luzindole (N-0774),melatonin receptor拮抗剂(ab145232)
Key features and details
- Competitive melatonin receptor antagonist
- CAS Number: 117946-91-5
- Purity: > 96%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Luzindole (N-0774),melatonin receptor拮抗剂 -
描述
Competitive melatonin receptor拮抗剂 -
别名
- N-0774
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生物学描述
Competitive melatonin receptor antagonist (IC50 = 1 μM). Shows selectivity towards melatonin 1B (Ki values are 45 and 603 nM for MEL-1B and MEL-1A respectively). Inhibits melatonin-induced pigment aggregation (IC50 = 2.1 μM) and shows neuroprotective effects in vivo. -
纯度
> 96% -
CAS编号
117946-91-5 -
化学结构
性能
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化学名称
N-[2-(2-Benzyl-1H-indol-3-yl)ethyl]acetamide -
分子量
292.38 -
分子式
C19H20N2O -
PubChem识别号
122162 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3 -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab145232 被引用在 3 文献中.
- Zhou Q et al. Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide. Mol Neurobiol 58:6552-6576 (2021). PubMed: 34585328
- Jiang S et al. Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats. J Inflamm Res 14:5919-5937 (2021). PubMed: 34803390
- Shuai Y et al. Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion. Theranostics 6:1899-917 (2016). PubMed: 27570559