Anti-Lunatic Fringe抗体(ab80439)

概述

  • 产品名称Anti-Lunatic Fringe抗体
    参阅全部 Lunatic Fringe 一抗
  • 描述
    兔多克隆抗体to Lunatic Fringe
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Saccharomyces cerevisiae
  • 免疫原

    Synthetic peptide corresponding to a region of human Lunatic Fringe

  • 阳性对照
    • Fetal muscle lysate.

性能

应用

Our Abpromise guarantee covers the use of ab80439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/62500.

靶标

  • 功能Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • 疾病相关Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • 序列相似性Belongs to the glycosyltransferase 31 family.
  • 翻译后修饰A soluble form may be derived from the membrane form by proteolytic processing.
  • 细胞定位Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3-N-acetylglucosaminyltransferase lunatic fringe antibody
    • Beta-1 antibody
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody
    • lfng antibody
    • LFNG_HUMAN antibody
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody
    • SCDO3 antibody
    see all

Anti-Lunatic Fringe antibody 图像

  • Anti-Lunatic Fringe antibody (ab80439) at 1 µg/ml + fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti Rabbit IgG at 1/50000 dilution

    Predicted band size : 42 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)

Anti-Lunatic Fringe antibody (ab80439)参考文献

ab80439 has not yet been referenced specifically in any publications.

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