概述

  • 产品名称Anti-LTK抗体
    参阅全部 LTK 一抗
  • 描述
    兔多克隆抗体to LTK
  • 特异性This antibody is expected to react with isoforms one and two of human LTK.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide : A sequence taken from within amino acids 800-864 of human LTK.

  • 阳性对照
    • Human K562 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab47072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 95 kDa (predicted molecular weight: 91 kDa).

靶标

  • 功能Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
  • 组织特异性Expressed in non-hematopoietic cell lines and T- and B-cell lines.
  • 疾病相关Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Leukocyte receptor tyrosine kinase antibody
    • Leukocyte tyrosine kinase antibody
    • Leukocyte tyrosine kinase receptor antibody
    • Ltk antibody
    • LTK_HUMAN antibody
    • Protein tyrosine kinase 1 antibody
    • TYK 1 antibody
    • TYK1 antibody
    see all

Anti-LTK antibody 图像

  • Anti-LTK antibody (ab47072) at 1 µg/ml + human K562 cell lysate

    Predicted band size : 91 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 120 kDa,33 kDa,40 kDa,50 kDa,63 kDa. We are unsure as to the identity of these extra bands.

Anti-LTK antibody (ab47072)参考文献

ab47072 has not yet been referenced specifically in any publications.

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