概述

  • 产品名称Anti-LTBR抗体
    参阅全部 LTBR 一抗
  • 描述
    兔多克隆抗体to LTBR
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide derived from an internal region of human LTBR.

  • 阳性对照
    • HeLa cells and extract, HepG2 cell extract.

性能

应用

Our Abpromise guarantee covers the use of ab70063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 48 kDa).
ELISA 1/40000.
ICC/IF 1/500 - 1/1000.

靶标

  • 功能Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
  • 序列相似性Contains 4 TNFR-Cys repeats.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD18 antibody
    • D12S370 antibody
    • LT beta R antibody
    • LTBETAR antibody
    • Ltbr antibody
    • Lymphotoxin B receptor antibody
    • Lymphotoxin beta receptor (TNFR superfamily, member 3) antibody
    • Lymphotoxin beta receptor antibody
    • Lymphotoxin-beta receptor antibody
    • TNF R III antibody
    • TNF-RIII antibody
    • TNFCR antibody
    • TNFR RP antibody
    • TNFR superfamily member 3 antibody
    • TNFR-III antibody
    • TNFR2 RP antibody
    • TNFR2RP antibody
    • TNFR3 antibody
    • TNFRII antibody
    • TNFRRP antibody
    • TNFRSF 3 antibody
    • TNFRSF3 antibody
    • TNR3_HUMAN antibody
    • Tumor necrosis factor C receptor antibody
    • Tumor necrosis factor receptor 2 related protein antibody
    • Tumor necrosis factor receptor 2-related protein antibody
    • Tumor necrosis factor receptor superfamily member 3 antibody
    • Tumor necrosis factor receptor superfamily member 3 precursor antibody
    • Tumor necrosis factor receptor type III antibody
    see all

Anti-LTBR antibody 图像

  • All lanes : Anti-LTBR antibody (ab70063) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HepG2 cell extract
    Lane 3 : HeLa cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.
  • HeLa cells with ab70063 at 1/500 dilution, with and without the immunising peptide.

Anti-LTBR antibody (ab70063)参考文献

This product has been referenced in:
  • Shen M  et al. Lymphotoxin ß receptor activation promotes bladder cancer in a nuclear factor-?B-dependent manner. Mol Med Rep 11:783-90 (2015). IHC-P ; Human . Read more (PubMed: 25369740) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (monocytes)
Loading amount 20 µg
Specification monocytes
Gel Running Conditions Reduced Denaturing (10%)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1.6% · Temperature: RT°C
Username

Abcam user community

Verified customer

提交于 Jan 26 2012

Thank you for your enquiry. I can confirm that Anti-LTBR antibody (ab70063) has been tested and guaranteed in human samples. For mouse samples, predicted to react means that the mouse sequence has high alignment to the human immunogen sequence...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"