概述

  • 产品名称
  • 描述
    兔多克隆抗体to LTBP2
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to internal sequence amino acids 241-376 of Human LTBP2.

  • 阳性对照
    • Human prostate tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/800. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    May play an integral structural role in elastic-fiber architectural organization and/or assembly.
  • 组织特异性
    Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
  • 疾病相关
    Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
    Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
  • 序列相似性
    Belongs to the LTBP family.
    Contains 20 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • 结构域
    Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C.
  • 翻译后修饰
    Contains hydroxylated asparagine residues.
  • 细胞定位
    Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C14orf141 antibody
    • Chromosome 14 open reading frame 141 antibody
    • Latent TGF beta binding protein 2 antibody
    • Latent transforming growth factor beta binding protein 2 antibody
    • Latent-transforming growth factor beta-binding protein 2 antibody
    • LTBP 2 antibody
    • LTBP 3 antibody
    • LTBP-2 antibody
    • Ltbp2 antibody
    • LTBP2_HUMAN antibody
    • LTBP3 antibody
    • MSTP 031 antibody
    • MSTP031 antibody
    see all

Anti-LTBP2 antibody 图像

  • ab121193 at 1/800 dilution staining LTBP2 in Paraffin-embedded Human Prostate tissue by Immunohistochemistry.

Anti-LTBP2 antibody (ab121193)参考文献

This product has been referenced in:
  • Wang C  et al. Latent Transforming Growth Factor ß Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma. Med Sci Monit 23:3232-3239 (2017). IHC-P ; Human . Read more (PubMed: 28669978) »

See 1 Publication for this product

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