This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 195 kDa.

Preliminary experiments in Mouse and Rat Eye lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

靶标

  • 功能
    May play an integral structural role in elastic-fiber architectural organization and/or assembly.
  • 组织特异性
    Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
  • 疾病相关
    Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
    Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
  • 序列相似性
    Belongs to the LTBP family.
    Contains 20 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • 结构域
    Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C.
  • 翻译后修饰
    Contains hydroxylated asparagine residues.
  • 细胞定位
    Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C14orf141 antibody
    • Chromosome 14 open reading frame 141 antibody
    • Latent TGF beta binding protein 2 antibody
    • Latent transforming growth factor beta binding protein 2 antibody
    • Latent-transforming growth factor beta-binding protein 2 antibody
    • LTBP 2 antibody
    • LTBP 3 antibody
    • LTBP-2 antibody
    • Ltbp2 antibody
    • LTBP2_HUMAN antibody
    • LTBP3 antibody
    • MSTP 031 antibody
    • MSTP031 antibody
    see all

实验方案

Anti-LTBP2 antibody (ab121005)参考文献

ab121005 has not yet been referenced specifically in any publications.

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