概述

  • 产品名称Anti-LRSAM1抗体
    参阅全部 LRSAM1 一抗
  • 描述
    兔多克隆抗体to LRSAM1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-723 of Human LRSAM1 (NP_001005373.1).

  • 阳性对照
    • Human liver tissue lysate, HeLa cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab103677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 84 kDa.

靶标

  • 功能E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
  • 组织特异性Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Charcot-Marie-Tooth disease 2P (CMT2P) [MIM:614436]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Contains 6 LRR (leucine-rich) repeats.
    Contains 1 RING-type zinc finger.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域The coiled coil domains interact with the SB domain of TSG101.
    The PTAP motifs mediate the binding to UEV domains.
  • 细胞定位Cytoplasm. Displays a punctuate distribution and localizes to a submembranal ring.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CMT2P antibody
    • E3 ubiquitin protein ligase LRSAM1 antibody
    • E3 ubiquitin-protein ligase LRSAM1 antibody
    • EC 6.3.2.- antibody
    • FLJ31641 antibody
    • hTAL antibody
    • Leucine rich repeat and sterile alpha motif containing 1 antibody
    • Leucine rich repeat and sterile alpha motif containing protein 1 antibody
    • Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody
    • LRSAM1 antibody
    • LRSM1_HUMAN antibody
    • OTTHUMP00000022174 antibody
    • OTTHUMP00000022175 antibody
    • RIFLE antibody
    • TAL antibody
    • Tsg101 associated ligase antibody
    • Tsg101-associated ligase antibody
    see all

Anti-LRSAM1 antibody 图像

  • Anti-LRSAM1 antibody (ab103677) at 5 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 84 kDa
  • Anti-LRSAM1 antibody (ab103677) at 5 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 84 kDa
  • All lanes : Anti-LRSAM1 antibody (ab103677) at 5 µg/ml

    Lane 1 : LSRAM1 transfected 293T cell lysate
    Lane 2 : 293T non-transfected cell lysate

    Lysates/proteins at 50 µg per lane.


    Predicted band size : 84 kDa

Anti-LRSAM1 antibody (ab103677)参考文献

ab103677 has not yet been referenced specifically in any publications.

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