概述

  • 产品名称Anti-LRRC6抗体
    参阅全部 LRRC6 一抗
  • 描述
    兔多克隆抗体to LRRC6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Guinea pig, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 71-120 (LNLALNNIEK IENLEGCEEL AKLDLTVNFI GELSSIKNLQ HNIHLKELFL) of Human LRRC6 (NP_036604).

  • 阳性对照
    • PANC1 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab98167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility.
  • 组织特异性Expressed predominantly in testis and in nasal epithelial cells.
  • 疾病相关Defects in LRRC6 are the cause of primary ciliary dyskinesia 19 (CILD19) [MIM:614935]. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • 序列相似性Belongs to the tilb protein family.
    Contains 1 CS domain.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • 细胞定位Cytoplasm. Cell projection > cilium.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Leucine rich repeat containing 6 antibody
    • Leucine rich repeat containing protein 6 antibody
    • Leucine rich testis specific protein antibody
    • Leucine-rich repeat-containing protein 6 antibody
    • Leucine-rich testis-specific protein antibody
    • Lrrc6 antibody
    • LRTP antibody
    • Protein TILB homolog antibody
    • Testis specific leucine rich repeat protein antibody
    • Testis-specific leucine-rich repeat protein antibody
    • TILB_HUMAN antibody
    • TSLRP antibody
    see all

Anti-LRRC6 antibody 图像

  • Anti-LRRC6 antibody (ab98167) at 1 µg/ml (in 5% skim milk / PBS buffer) + PANC1 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 54 kDa

Anti-LRRC6 antibody (ab98167)参考文献

ab98167 has not yet been referenced specifically in any publications.

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