Vijayakumar S et al.Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.Genes Cancer 8:613-627 (2017).
Liu CC et al.Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease.Neuron N/A:N/A (2014).
Du C et al.MiR-126-3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2.J Transl Med 12:259 (2014).
van Dinther M et al.Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.PLoS One 8:e62295 (2013).
Goel S et al.Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts.J Biol Chem 287:16454-66 (2012).
Khan Z et al.Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.Mol Cell Biol 27:7291-301 (2007).