概述

  • 产品名称
  • 描述
    山羊多克隆抗体to LRP4
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    C-SNPSYRTSTQEVK

    , corresponding to internal sequence amino acids 1765-1777 of Human LRP4 (NP_002325.2).

  • 阳性对照
    • Human brain (cerebral cortex) lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab85697 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab85697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 200 kDa (predicted molecular weight: 216 kDa).

靶标

  • 功能
    Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
  • 组织特异性
    Expressed in several regions of the brain.
  • 疾病相关
    Defects in LRP4 are the cause of Cenani-Lenz syndactyly syndrome (CLSS) [MIM:212780]. It is a congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs.
  • 序列相似性
    Belongs to the LDLR family.
    Contains 3 EGF-like domains.
    Contains 8 LDL-receptor class A domains.
    Contains 20 LDL-receptor class B repeats.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0816 antibody
    • LDLR dan antibody
    • Low density lipoprotein receptor related protein 4 antibody
    • Low-density lipoprotein receptor-related protein 4 antibody
    • LRP-4 antibody
    • LRP10 antibody
    • Lrp4 antibody
    • LRP4_HUMAN antibody
    • MEGF7 antibody
    • Multiple epidermal growth factor like domains 7 antibody
    • Multiple epidermal growth factor-like domains 7 antibody
    see all

图片

实验方案

文献

This product has been referenced in:
  • Selcen D  et al. Impaired Synaptic Development, Maintenance, and Neuromuscular Transmission in LRP4-Related Myasthenia. JAMA Neurol 72:889-96 (2015). Read more (PubMed: 26052878) »
  • Ohkawara B  et al. LRP4 third ß-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner. Hum Mol Genet N/A:N/A (2013). Read more (PubMed: 24234652) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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