概述

  • 产品名称Anti-LRP4抗体
    参阅全部 LRP4 一抗
  • 描述
    山羊多克隆抗体to LRP4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to an internal region of Human LRP4.

  • 阳性对照
    • Human Colon, Epithelium tissue; Human cerebral cortex lysate.

性能

应用

Our Abpromise guarantee covers the use of ab122923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 212 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
  • 组织特异性Expressed in several regions of the brain.
  • 疾病相关Defects in LRP4 are the cause of Cenani-Lenz syndactyly syndrome (CLSS) [MIM:212780]. It is a congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs.
  • 序列相似性Belongs to the LDLR family.
    Contains 3 EGF-like domains.
    Contains 8 LDL-receptor class A domains.
    Contains 20 LDL-receptor class B repeats.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Corin antibody
    • KIAA0816 antibody
    • LDLR dan antibody
    • Low density lipoprotein receptor related protein 4 antibody
    • Low-density lipoprotein receptor-related protein 4 antibody
    • LRP-4 antibody
    • LRP10 antibody
    • Lrp4 antibody
    • LRP4_HUMAN antibody
    • MEGF7 antibody
    • Multiple epidermal growth factor like domains 7 antibody
    • Multiple epidermal growth factor-like domains 7 antibody
    see all

Anti-LRP4 antibody 图像

  • ab122923, at 3.75 µg/ml, staining LRP4 in Formalin-fixed, Paraffin-embedded Human Colon, epithelium tissue by Immunohistochemistry.
  • Anti-LRP4 antibody (ab122923) at 0.1 µg/ml + Human cerebral cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 212 kDa

Anti-LRP4 antibody (ab122923)参考文献

ab122923 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab122923.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"