Anti-Lrp2 / Megalin抗体(ab115316)


  • 产品名称
    Anti-Lrp2 / Megalin抗体
    参阅全部 Lrp2 / Megalin 一抗
  • 描述
    兔多克隆抗体to Lrp2 / Megalin
  • 经测试应用
    适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, conjugated to KLH, from a region of Human Lrp2/Megalin.

  • 阳性对照
    • Human kidney cortex tissue


Our Abpromise guarantee covers the use of ab115316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • 功能
    Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
  • 组织特异性
    Absorptive epithelia, including renal proximal tubules.
  • 疾病相关
    Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity.
  • 序列相似性
    Belongs to the LDLR family.
    Contains 17 EGF-like domains.
    Contains 36 LDL-receptor class A domains.
    Contains 37 LDL-receptor class B repeats.
  • 细胞定位
    Membrane. Membrane > coated pit.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Calcium sensor protein antibody
    • DBS antibody
    • Glycoprotein 330 antibody
    • gp330 antibody
    • Heymann nephritis antigen homolog antibody
    • Low-density lipoprotein receptor-related protein 2 antibody
    • LRP-2 antibody
    • Lrp2 antibody
    • LRP2_HUMAN antibody
    • Megalin antibody
    see all

Anti-Lrp2 / Megalin antibody 图像

  • ab115316 at 2.5ug/ml staining Lrp2/Megalin in Human kidney cortex tissue by immunohistochemistry. Following primary incubation the slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Lrp2 / Megalin antibody (ab115316)参考文献

ab115316 has not yet been referenced specifically in any publications.

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Expiration date: June 2nd, 2012

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