概述

  • 产品名称Anti-LRIG1抗体
    参阅全部 LRIG1 一抗
  • 描述
    鸡多克隆抗体to LRIG1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to part of the cytoplasmic tail (C-terminal part).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS, pH 8
  • Concentration information loading...
  • 纯度IgY fraction
  • 克隆多克隆
  • 同种型IgY
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1 µg/ml, performed on lysates from over-expressing cells. Predicted molecular weight: 120 kDa.

    LRIG1 protein migrates during denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134kDa, and as two fragments corresponding to an N-terminal 111kDa species and a C-terminal 32kDa species. Under non-reducing conditions, both apparent monomers and apparent higher molecular weight complexes were evident.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
    • 组织特异性Widely expressed.
    • 序列相似性Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 15 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
    • 结构域The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Leucine rich repeat protein antibody
      • Leucine rich repeat protein LRIG1 antibody
      • leucine rich repeats and immunoglobulin like domains 1 antibody
      • Leucine-rich repeats and immunoglobulin-like domains protein 1 antibody
      • leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1 antibody
      • LIG 1 antibody
      • LIG-1 antibody
      • LIG1 antibody
      • Lrig1 antibody
      • LRIG1_HUMAN antibody
      • Ortholog of mouse integral membrane glycoprotein LIG 1 antibody
      see all

    Anti-LRIG1 antibody (ab58853)参考文献

    ab58853 has not yet been referenced specifically in any publications.

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