概述

  • 产品名称
  • 描述
    鸡多克隆抗体to LRIG1
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to part of the cytoplasmic tail (C-terminal part).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS, pH 8
  • Concentration information loading...
  • 纯度
    IgY fraction
  • 克隆
    多克隆
  • 同种型
    IgY
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: Use at a concentration of 1 µg/ml, performed on lysates from over-expressing cells. Predicted molecular weight: 120 kDa.

    LRIG1 protein migrates during denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134kDa, and as two fragments corresponding to an N-terminal 111kDa species and a C-terminal 32kDa species. Under non-reducing conditions, both apparent monomers and apparent higher molecular weight complexes were evident.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
    • 组织特异性
      Widely expressed.
    • 序列相似性
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 15 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
    • 结构域
      The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Leucine rich repeat protein antibody
      • Leucine rich repeat protein LRIG1 antibody
      • leucine rich repeats and immunoglobulin like domains 1 antibody
      • Leucine-rich repeats and immunoglobulin-like domains protein 1 antibody
      • leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1 antibody
      • LIG 1 antibody
      • LIG-1 antibody
      • LIG1 antibody
      • Lrig1 antibody
      • LRIG1_HUMAN antibody
      • Ortholog of mouse integral membrane glycoprotein LIG 1 antibody
      see all

    实验方案

    文献

    ab58853 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab58853.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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