概述

  • 产品名称Anti-LRDD抗体
    参阅全部 LRDD 一抗
  • 描述
    兔多克隆抗体to LRDD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 143-192 (

    RLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLA

    ) of Human LRDD isoform 3.

  • 阳性对照
    • Human Fetal Liver Lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 83 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.
  • 细胞定位Cytoplasm. Nucleus.
  • 数据库链接
  • 别名
    • DKFZp434D229 antibody
    • Leucine rich repeats and death domain containing antibody
    • Leucine-rich repeats and death domain containing antibody
    • MGC16925 antibody
    • p53-induced protein with a death domain antibody
    • PIDD antibody
    see all

Anti-LRDD antibody 图像

  • Anti-LRDD antibody (ab99149) at 1 µg/ml + Human Fetal Liver Lysate at 10 µg

    Predicted band size : 83 kDa

Anti-LRDD antibody (ab99149)参考文献

ab99149 has not yet been referenced specifically in any publications.

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