概述

  • 产品名称Anti-LPP抗体
    参阅全部 LPP 一抗
  • 描述
    山羊多克隆抗体to LPP
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-RNDSDPTYGQQGHP

    , corresponding to internal sequence amino acids 310-323 of Human LPP (NP_005569.1).

  • 阳性对照
    • HepG2 cell lysate and Human placenta lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab99281 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 66 kDa). An approximately 85kDa band is observed in Human Placenta lysates and in lysates of the cell line HepG2. The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources.

靶标

  • 功能May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
  • 组织特异性Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
  • 疾病相关Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
    Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
    Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
    Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with MLL is associated with acute monoblastic leukemia.
  • 序列相似性Belongs to the zyxin/ajuba family.
    Contains 3 LIM zinc-binding domains.
  • 细胞定位Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and MLL.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp779O0231 antibody
    • FLJ30652 antibody
    • FLJ41512 antibody
    • LIM domain containing preferred translocation partner in lipoma antibody
    • LIM domain-containing preferred translocation partner in lipoma antibody
    • LIM protein antibody
    • Lipoma preferred partner antibody
    • Lipoma-preferred partner antibody
    • lpp antibody
    • LPP_HUMAN antibody
    see all

Anti-LPP antibody 图像

  • Anti-LPP antibody (ab99281) at 0.1 µg/ml + HepG2 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 66 kDa

Anti-LPP antibody (ab99281)参考文献

ab99281 has not yet been referenced specifically in any publications.

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