Anti-LOX 1抗体[LOX19-22] (ab53202)

概述

  • 产品名称Anti-LOX 1抗体[LOX19-22]
    参阅全部 LOX 1 一抗
  • 描述
    小鼠单克隆抗体[LOX19-22] to LOX 1
  • 特异性Human recombinant sLOX-158-273
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human recombinant soluble LOX1 expressed in E. coli.

性能

应用

Our Abpromise guarantee covers the use of ab53202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 组织特异性Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
  • 疾病相关Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
    Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
  • 序列相似性Contains 1 C-type lectin domain.
  • 结构域The cytoplasmic region is required for subcellular sorting on the cell surface.
    The C-type lectin domain mediates the recognition and binding of oxLDL.
  • 翻译后修饰The intrachain disulfide-bonds prevent N-glycosylation at some sites.
    N-glycosylated.
  • 细胞定位Cell membrane. Secreted. A secreted form also exists.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-type lectin domain family 8 member A antibody
    • CLEC8A antibody
    • hLOX 1 antibody
    • hLOX-1 antibody
    • Lectin like oxidized LDL receptor 1 antibody
    • Lectin like oxLDL receptor 1 antibody
    • Lectin type oxidized LDL receptor 1 antibody
    • Lectin-like oxidized LDL receptor 1 antibody
    • Lectin-like oxLDL receptor 1 antibody
    • Lectin-type oxidized LDL receptor 1 antibody
    • low density lipoprotein oxidized, receptor 1 antibody
    • LOX-1 antibody
    • LOXIN antibody
    • Olr1 antibody
    • OLR1_HUMAN antibody
    • Ox LDL receptor 1 antibody
    • Ox-LDL receptor 1 antibody
    • Oxidised low density lipoprotein (lectin like) receptor 1 antibody
    • Oxidized low density lipoprotein receptor 1 antibody
    • Oxidized low density lipoprotein receptor 1 soluble form antibody
    • Oxidized low-density lipoprotein receptor 1 antibody
    • SCARE1 antibody
    • Scavenger receptor class E, member 1 antibody
    • SLOX1 antibody
    • soluble form antibody
    • SR-EI antibody
    see all

Anti-LOX 1 antibody [LOX19-22] (ab53202)参考文献

ab53202 has not yet been referenced specifically in any publications.

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