Anti-LONP1/Lon抗体(ab103809)
Key features and details
- Rabbit polyclonal to LONP1/Lon
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-LONP1/Lon抗体
参阅全部 LONP1/Lon 一抗 -
描述
兔多克隆抗体to LONP1/Lon -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant full length protein corresponding to Human LONP1/Lon aa 1-959.
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阳性对照
- Human kidney, Mouse kidney, HepG2, transfected 293T cell line
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab103809于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa.
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说明 |
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WB
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa. |
靶标
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功能
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. -
组织特异性
Duodenum, heart, lung and liver, but not thymus. -
疾病相关
CODAS syndrome -
序列相似性
Belongs to the peptidase S16 family.
Contains 1 Lon domain. -
细胞定位
Mitochondrion matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 9361 Human
- Entrez Gene: 74142 Mouse
- Omim: 605490 Human
- SwissProt: P36776 Human
- SwissProt: Q8CGK3 Mouse
- Unigene: 350265 Human
- Unigene: 329136 Mouse
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别名
- hLON antibody
- hLON ATP dependent protease antibody
- LON antibody
see all
图片
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Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa -
All lanes : Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml
Lane 1 : LONP1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 106 kDa
数据表及文件
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Datasheet download
文献 (24)
ab103809 被引用在 24 文献中.
- Chattopadhyay M et al. The portrait of liver cancer is shaped by mitochondrial genetics. Cell Rep 38:110254 (2022). PubMed: 35045282
- Cai G et al. Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response. Front Pharmacol 13:859978 (2022). PubMed: 35652041
- Zanini G et al. Differential Expression of Lonp1 Isoforms in Cancer Cells. Cells 11:N/A (2022). PubMed: 36497197
- Gao X et al. ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease. Cell Death Dis 12:701 (2021). PubMed: 34262025
- Lee Y et al. General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain. Neurotoxicology 82:1-8 (2021). PubMed: 33144179