概述

  • 产品名称Anti-LMBRD1抗体
    参阅全部 LMBRD1 一抗
  • 描述
    兔多克隆抗体to LMBRD1
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, from the C terminus of Human LMBRD1.

  • 阳性对照
    • Human breast or myenteric plexus (colon) tissue.

性能

应用

Our Abpromise guarantee covers the use of ab117641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
  • 组织特异性Isoform 3 is expressed in liver.
  • 疾病相关Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12.
  • 序列相似性Belongs to the LIMR family. LMBRD1 subfamily.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Lysosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HDAg-L-interacting protein NESI antibody
    • LMBD1_HUMAN antibody
    • LMBR1 domain-containing protein 1 antibody
    • lmbrd1 antibody
    • Nuclear export signal-interacting protein antibody
    • Probable lysosomal cobalamin transporter antibody
    see all

Anti-LMBRD1 antibody 图像

  • Human breast, Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117641 at 5µg/ml.
  • Human Myenteric Plexus (colon), Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117641 at 5µg/ml.

Anti-LMBRD1 antibody (ab117641)参考文献

ab117641 has not yet been referenced specifically in any publications.

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