概述

  • 产品名称Anti-LMBRD1抗体
    参阅全部 LMBRD1 一抗
  • 描述
    兔多克隆抗体to LMBRD1
  • 特异性LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members.
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    An 18 amino acid peptide from the C-terminus of Human LMBRD1 (NP_060838)

  • 阳性对照
    • Human Brain Tissue Lysate

性能

应用

Our Abpromise guarantee covers the use of ab105419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
  • 组织特异性Isoform 3 is expressed in liver.
  • 疾病相关Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12.
  • 序列相似性Belongs to the LIMR family. LMBRD1 subfamily.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Lysosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HDAg-L-interacting protein NESI antibody
    • LMBD1_HUMAN antibody
    • LMBR1 domain-containing protein 1 antibody
    • lmbrd1 antibody
    • Nuclear export signal-interacting protein antibody
    • Probable lysosomal cobalamin transporter antibody
    see all

Anti-LMBRD1 antibody 图像

  • Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.
  • Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.

  • Anti-LMBRD1 antibody (ab105419) at 1 µg/ml + Human brain tissue lysate at 15 µg

    Predicted band size : 61 kDa

Anti-LMBRD1 antibody (ab105419)参考文献

ab105419 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105419.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"