概述

  • 产品名称Anti-LMBR1抗体
    参阅全部 LMBR1 一抗
  • 描述
    小鼠单克隆抗体to LMBR1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: SRMFTVMGQL LVKPTILEDL DEQIYIITLE EEALQRRLNG LSSSVEYNIM ELEQELENVK TLKTKLERRK KASAWERNLV YP, corresponding to amino acids 214-296 of Human LMBR1

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative membrane receptor.
    • 组织特异性Widely expressed with strongest expression in heart and pancreas.
    • 疾病相关Defects in LMBR1 are associated with preaxial polydactyly type 2 (PPD2) [MIM:174500]; also known as polydactyly of triphalangeal thumb. Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal. The mutations do not change the normal expression of LMBR1, but alter the expression of SHH by disrupting a long-range, cis-regulatory element of that gene.
      Defects in LMBR1 are the cause of acheiropody (ACHP) [MIM:200500]. Acheiropody is a very rare condition characterized by bilateral congenital amputations of the hands and feet. The specific malformative phenotype consists of a complete amputation of the distal epiphysis of the humerus, amputation of the tibial diaphysis, and aplasia of the radius, ulna, fibula, and of all the bones of the hands and feet. This syndrome of autosomal recessive inheritance has only been observed in Brazil so far.
      Defects in LMBR1 are a cause of syndactyly type 4 (SDYT4) [MIM:186200]. SDYT4 is a very rare congenital distal limb malformation characterized by complete bilateral syndactyly (involving all digits 1 to 5). A frequent association with polydactyly (with six metacarpals and six digits) has been reported. Feet are affected occasionally. The condition is inherited as an autosomal dominant trait.
    • 序列相似性Belongs to the LIMR family.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACHP antibody
      • C7orf2 antibody
      • DIF 14 antibody
      • DIF14 antibody
      • Differentiation related gene 14 antibody
      • Differentiation related gene 14 protein antibody
      • Differentiation-related gene 14 protein antibody
      • FLJ11665 antibody
      • Limb region 1 homolog (mouse) antibody
      • Limb region 1 homolog antibody
      • Limb region 1 protein antibody
      • Limb region 1 protein homolog antibody
      • LMBR 1 antibody
      • LMBR1 antibody
      • LMBR1_HUMAN antibody
      • OTTHUMP00000211720 antibody
      • PPD 2 antibody
      • PPD2 antibody
      • TPT antibody
      see all

    Anti-LMBR1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56402 LMBR1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-LMBR1 antibody (ab56402)参考文献

    ab56402 has not yet been referenced specifically in any publications.

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