概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      CRVSSRKRHPAGPPGE
    • 氨基酸
      661 to 675

技术指标

Our Abpromise guarantee covers the use of ab45843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

常规信息

  • 别名
    • HGL
    • Human giant larvae homolog
    • L2GL2
    • L2GL2_HUMAN
    • Lethal 2 giant larvae protein homolog 2
    • Lethal giant larvae homolog 2
    • Lethal(2) giant larvae protein homolog 2
    • LGL2
    • LLGL2
    see all
  • 功能
    Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
  • 序列相似性
    Belongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • 翻译后修饰
    Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.
  • 细胞定位
    Cytoplasm. Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
  • Information by UniProt

文献

ab45843 has not yet been referenced specifically in any publications.

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