概述

  • 产品名称Anti-LKB1抗体
    参阅全部 LKB1 一抗
  • 描述
    兔多克隆抗体to LKB1
  • 特异性ab61122 detects endogenous levels of total LKB1 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic non-phosphopeptide derived from human LKB1 around the phosphorylation site of threonine 189 (G-G-TP-L-K).

  • 阳性对照
    • Extracts from HeLa cells treated with Serum (20%, 15mins).

性能

应用

Our Abpromise guarantee covers the use of ab61122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).
ELISA 1/5000.

靶标

  • 功能Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • 组织特异性Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • 疾病相关Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated by a cAMP-dependent protein kinase.
  • 细胞定位Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hLKB1 antibody
    • Liver kinase B1 antibody
    • LKB1 antibody
    • PJS antibody
    • Polarization related protein LKB1 antibody
    • Renal carcinoma antigen NY-REN-19 antibody
    • Serine/Threonine Kinase 11 antibody
    • Serine/threonine protein kinase 11 antibody
    • Serine/threonine protein kinase LKB1 antibody
    • Serine/threonine protein kinase STK11 antibody
    • Serine/threonine-protein kinase 11 antibody
    • Serine/threonine-protein kinase LKB1 antibody
    • Serine/threonine-protein kinase XEEK1 antibody
    • Stk11 antibody
    • STK11_HUMAN antibody
    see all

Anti-LKB1 antibody 图像

  • All lanes : Anti-LKB1 antibody (ab61122) at 1/500 dilution

    Lane 1 : Extracts from HeLa cells treated with Serum (20%, 15mins)
    Lane 2 : Extracts from HeLa cells treated with Serum (20%, 15mins) with immunising LKB1 peptide


    Predicted band size : 48 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)

Anti-LKB1 antibody (ab61122)参考文献

ab61122 has not yet been referenced specifically in any publications.

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