概述

  • 产品名称
  • 描述
    兔多克隆抗体to Livin
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-211 of Human Livin (AAH14475).

  • 阳性对照
    • WB: A431, H1299, HeLa and HepG2 cell lysates IHC-P: Cal27 xenograft ICc/IF: Hela cell

性能

应用

Our Abpromise guarantee covers the use of ab97350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • 组织特异性
    Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • 序列相似性
    Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • 细胞定位
    Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Baculoviral IAP repeat containing 7 antibody
    • Baculoviral IAP repeat containing protein 7 antibody
    • Baculoviral IAP repeat-containing protein 7 antibody
    • BIRC 7 antibody
    • birc7 antibody
    • BIRC7_HUMAN antibody
    • KIAP antibody
    • Kidney inhibitor of apoptosis protein antibody
    • Livin antibody
    • Livin inhibitor of apotosis antibody
    • Melanoma inhibitor of apoptosis protein antibody
    • ML IAP antibody
    • ML-IAP antibody
    • MLIAP antibody
    • RING finger protein 50 antibody
    • RNF 50 antibody
    • RNF50 antibody
    see all

图片

  • Anti-Livin antibody (ab97350) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 33 kDa



    12% SDS PAGE
  • ab97350, at a 1/200 dilution, staining Livin in paraformaldehyde fixed HeLa cell by immunofluorescence.
    The lower image shows ab97350 merged with DNA probe.
  • ab97350, at a 1/100 dilution, staining Livin in paraffin embedded Cal27 xenograft by Immunohistochemistry.

文献

This product has been referenced in:
  • Liu S  et al. Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy. Oncol Lett 15:7707-7715 (2018). Read more (PubMed: 29740490) »
  • Su QB  et al. Livin serves as a prognostic marker for mid-distal rectal cancer and a target of mid-distal rectal cancer treatment. Oncol Lett 14:7759-7766 (2017). Read more (PubMed: 29344221) »

See all 3 Publications for this product

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