概述

  • 产品名称Anti-Livin抗体
    参阅全部 Livin 一抗
  • 描述
    兔多克隆抗体to Livin
  • 特异性Detects both the alpha and beta (short and long) isoforms of Livin.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    CRAPVRSRVRTFLS

    , corresponding to amino acids 264 - 280 (short form) or 281 - 298 (long form) of Human Livin.

  • 阳性对照
    • WB: Raji cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab5393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
WB
  • 应用说明WB: Use at a concentration of 2 - 4 µg/ml. Detects bands of approximately 30 kDa (possibly short form) + 33 kDa (long form).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
    • 组织特异性Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
    • 序列相似性Belongs to the IAP family.
      Contains 1 BIR repeat.
      Contains 1 RING-type zinc finger.
    • 细胞定位Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Baculoviral IAP repeat containing 7 antibody
      • Baculoviral IAP repeat containing protein 7 antibody
      • Baculoviral IAP repeat-containing protein 7 antibody
      • BIRC 7 antibody
      • birc7 antibody
      • BIRC7_HUMAN antibody
      • KIAP antibody
      • Kidney inhibitor of apoptosis protein antibody
      • Livin antibody
      • Livin inhibitor of apotosis antibody
      • Melanoma inhibitor of apoptosis protein antibody
      • ML IAP antibody
      • ML-IAP antibody
      • MLIAP antibody
      • RING finger protein 50 antibody
      • RNF 50 antibody
      • RNF50 antibody
      see all

    Anti-Livin antibody 图像

    • Anti-Livin antibody (ab5393) at 4 µg/ml + Human Raji cell lysate

      Observed band size : 33 kDa (why is the actual band size different from the predicted?)
    • Immunofluorescence of Livin in Human Small Intestine cells using ab5393 at 20 ug/ml.

    Anti-Livin antibody (ab5393)参考文献

    ab5393 has not yet been referenced specifically in any publications.

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