Anti-LITAF抗体[AT5C10] (ab89597)

概述

  • 产品名称Anti-LITAF抗体[AT5C10]
    参阅全部 LITAF 一抗
  • 描述
    小鼠单克隆抗体[AT5C10] to LITAF
  • 经测试应用适用于: WB, Indirect ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human LITAF purified from E. coli, amino acids 1-161 (NP_004853)

  • 阳性对照
    • HeLa cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab89597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/3000. Predicted molecular weight: 17 kDa.
Indirect ELISA Use at an assay dependent dilution.

靶标

  • 功能Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
  • 组织特异性Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
  • 疾病相关Defects in LITAF are the cause of Charcot-Marie-Tooth disease type 1C (CMT1C) [MIM:601098]. CMT1C is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
    Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation.
  • 结构域The WW-binding motif mediates interaction with WWOX and, probably NEDD4.
  • 细胞定位Lysosome membrane. Associated with membranes of lysosomes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Lipopolysaccharide induced TNF alpha factor antibody
    • CMT1C antibody
    • FLJ38636 antibody
    • Lipopolysaccharide induced TNF alpha factor antibody
    • Lipopolysaccharide induced TNF factor antibody
    • Lipopolysaccharide induced tumor necrosis factor alpha factor antibody
    • Lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody
    • LITAF antibody
    • LITAF_HUMAN antibody
    • LPS induced TNF alpha factor antibody
    • LPS-induced TNF-alpha factor antibody
    • MGC116698 antibody
    • MGC116700 antibody
    • MGC116701 antibody
    • MGC125274 antibody
    • MGC125275 antibody
    • MGC125276 antibody
    • p53 induced gene 7 protein antibody
    • p53-induced gene 7 protein antibody
    • PIG 7 antibody
    • PIG7 antibody
    • SIMPLE antibody
    • Small integral membrane protein of lysosome/late endosome antibody
    • TP53I7 antibody
    • Tumor protein p53 inducible protein 7 antibody
    see all

Anti-LITAF antibody [AT5C10] 图像

  • Anti-LITAF antibody [AT5C10] (ab89597) at 1/2000 dilution + HeLa cell lysate at 20 µg

    Secondary
    goat anti-mouse HRP
    Developed using the ECL technique

    Predicted band size : 17 kDa
    Observed band size : 23 kDa (why is the actual band size different from the predicted?)

Anti-LITAF antibody [AT5C10] (ab89597)参考文献

ab89597 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89597.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"