概述
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产品名称Anti-LITAF抗体
参阅全部 LITAF 一抗 -
描述兔多克隆抗体to LITAF
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经测试应用适用于: WBmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat, Cow
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免疫原
Recombinant protein fragment corresponding to a region within amino acids 1 - 132 of Human LITAF (NP_004853).
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阳性对照
- HepG2 and HeLa cell lysates
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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存储溶液Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0 -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab96338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 17 for isoform 1 , for isoform 2, 24 kDa. |
靶标
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功能Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
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组织特异性Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
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疾病相关Defects in LITAF are the cause of Charcot-Marie-Tooth disease type 1C (CMT1C) [MIM:601098]. CMT1C is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation. -
结构域The WW-binding motif mediates interaction with WWOX and, probably NEDD4.
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细胞定位Lysosome membrane. Associated with membranes of lysosomes.
- Information by UniProt
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数据库链接
- Entrez Gene: 520564 Cow
- Entrez Gene: 9516 Human
- Entrez Gene: 65161 Rat
- Omim: 603795 Human
- SwissProt: Q99732 Human
- SwissProt: Q9JLJ0 Mouse
- SwissProt: P0C0T0 Rat
- Unigene: 459940 Human
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别名
- Lipopolysaccharide induced TNF alpha factor antibody
- CMT1C antibody
- FLJ38636 antibody
see all
Anti-LITAF antibody 图像
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Western blot - LITAF antibody (ab96338)Anti-LITAF antibody (ab96338) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size : 17 for isoform 1 , for isoform 2, 24 kDa
Anti-LITAF antibody (ab96338)参考文献
ab96338 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"