Anti-Lipoprotein lipase抗体(ab123134)

概述

  • 产品名称
    Anti-Lipoprotein lipase抗体
    参阅全部 Lipoprotein lipase 一抗
  • 描述
    兔多克隆抗体to Lipoprotein lipase
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 299-327 of Human Lipoprotein lipase (NP_000228.1)

  • 阳性对照
    • HL-60 cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab123134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

靶标

  • 功能
    The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
  • 疾病相关
    Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
  • 序列相似性
    Belongs to the AB hydrolase superfamily. Lipase family.
    Contains 1 PLAT domain.
  • 翻译后修饰
    Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
  • 细胞定位
    Cell membrane. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC 3.1.1 antibody
    • EC 3.1.1.34 antibody
    • HDLCQ11 antibody
    • LIPD antibody
    • LIPL_HUMAN antibody
    • Lipoprotein lipase antibody
    • LPL antibody
    • LPL protein antibody
    • MGC137861 antibody
    see all

图片

  • Anti-Lipoprotein lipase antibody (ab123134) at 1/100 dilution + HL-60 cell line lysates at 35 µg/ml

    Predicted band size : 53 kDa

实验方案

文献

ab123134 has not yet been referenced specifically in any publications.

客户评价及客户问答

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