Anti-Lipoic Acid抗体(ab58724)
Key features and details
- Rabbit polyclonal to Lipoic Acid
- Suitable for: WB, IHC-Fr, ELISA, IHC-P
- Reacts with: Species independent
- Isotype: IgG
概述
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产品名称
Anti-Lipoic Acid抗体 -
描述
兔多克隆抗体to Lipoic Acid -
宿主
Rabbit -
特异性
Recognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. -
经测试应用
适用于: WB, IHC-Fr, ELISA, IHC-Pmore details -
种属反应性
与反应: Species independent -
免疫原
Lipoic acid conjugated to KLH
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.50
Constituents: Whole serum, 50% Glycerol -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab58724于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 1 kDa.
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IHC-Fr |
1/50 - 1/500.
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ELISA |
1/500 - 1/1000.
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IHC-P |
1/50 - 1/500.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 1 kDa. |
IHC-Fr
1/50 - 1/500. |
ELISA
1/500 - 1/1000. |
IHC-P
1/50 - 1/500. |
靶标
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相关性
Lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
数据表及文件
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SDS download
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Datasheet download
文献 (16)
ab58724 被引用在 16 文献中.
- Przybyla-Toscano J et al. Protein lipoylation in mitochondria requires Fe-S cluster assembly factors NFU4 and NFU5. Plant Physiol 188:997-1013 (2022). PubMed: 34718778
- Pamukcu S et al. Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma. PLoS Pathog 17:e1010096 (2021). PubMed: 34793583
- Qian S et al. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance. Biosci Rep 40:N/A (2020). PubMed: 32440681
- Nowinski SM et al. Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. Elife 9:N/A (2020). PubMed: 32804083
- Toshniwal AG et al. ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development. Dev Cell 49:473-489.e9 (2019). PubMed: 31063760