概述

  • 产品名称Lipin 2肽(882-896)

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列(C)YWRDPIPEVDLDDLS
    • 氨基酸882 to 896

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Lipin 2 antibody (ab28765)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • KIAA0249
    • Lipin-2
    • Lipin2
    • LPIN 2
    • LPIN2
    • LPIN2_HUMAN
    • OTTHUMP00000162242
    • Phosphatidate phosphatase LPIN2
    see all
  • 功能Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
  • 组织特异性Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
  • 疾病相关Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
  • 序列相似性Belongs to the lipin family.
  • 结构域Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
  • Information by UniProt

Lipin 2 peptide (882-896) (ab45703)参考文献

ab45703 has not yet been referenced specifically in any publications.

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